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The Pituitary Society Consensus defined resistance as lack of normalization of prolactin serum levels or lack of relevant mass shrinkage (30% reduction in maximum diameter) when treated with standard dopamine agonist doses (7,5-10mg per day of bromocriptine or 2.0 mg per week of cabergoline) for at least 6 months (45)

Difficulties consist of erratic absorption, skin irritation from topical formulations, and no definitive timing recommendation with respect to ovulation or ART

The cost of Ozempic (Semaglutide) starts at around $915 per injection pen without insurance, varying by dosage, number of pens, and pharmacy selection

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